Role of DNA topoisomerase I in the replication of herpes simplex virus type 2

descriptionPublicationkeyboard_double_arrow_right Article 01 Mar 1990 English Publisher:Springer Science and Business Media LLCJournal:Archives of Virology, volume 110, pages 121-127 (issn: 0304-8608, eissn: 1432-8798,

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Authors: Y, Yamada; N, Yamamoto; K, Maeno; Y, Nishiyama;

doi: 10.1007/bf01310708

pmid: 2155595

Role of DNA topoisomerase I in the replication of herpes simplex virus type 2

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Abstract

Camptothecin (CPT), a specific inhibitor of DNA topoisomerase I, effectively inhibited the replication of herpes simplex virus type 2 (HSV-2). CPT was found to reduce the level of immediate early viral mRNA in a dose-response manner. On the other hand, we could not find any evidence that a novel DNA topoisomerase I was induced in HSV-2-infected cells. Our observations suggest that host cell DNA topoisomerase I is involved in the replication of HSV-2.

Related Organizations

Nagoya University
Japan

Keywords

DNA Topoisomerases, Type I, Dose-Response Relationship, Drug, Depression, Chemical, Enzyme Induction, Simplexvirus, Camptothecin, Viral Plaque Assay, Topoisomerase I Inhibitors, Virus Replication

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