Homology between feline herpesvirus-1 and canine herpesvirus

descriptionPublicationkeyboard_double_arrow_right Article 01 Mar 1990 English Publisher:Springer Science and Business Media LLCJournal:Archives of Virology, volume 115, pages 139-145 (issn: 0304-8608, eissn: 1432-8798,

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Authors: P A, Rota; R K, Maes;

doi: 10.1007/bf01310631

pmid: 2174232

Homology between feline herpesvirus-1 and canine herpesvirus

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Abstract

The purpose of this study was to determine the extent of the relatedness between feline herpesvirus-1 (FHV-1) and canine herpesvirus (CHV). Immunoprecipitation studies using antisera to FHV-1 and CHV revealed that both share virion glycoprotein antigens with apparent molecular weights of approximately 60 and 68 kDa. Two non-glycosylated, virion-associated antigens of each virus also displayed weaker cross reactivity. Southern blot hybridization experiments indicated that restriction fragments which represented approximately 51% of the FHV-1 genome hybridized to CHV DNA under conditions which allowed less than 7% base pair mismatch. This is the first molecular characterization of cross-reactivity between FHV-1 and another herpesvirus.

Related Organizations

Michigan State University
United States

Keywords

Restriction Mapping, Nucleic Acid Hybridization, Herpesviridae Infections, Cross Reactions, Cat Diseases, Blotting, Southern, Dogs, Herpesvirus 1, Canid, Sequence Homology, Nucleic Acid, DNA, Viral, Cats, Animals, Electrophoresis, Polyacrylamide Gel, Dog Diseases, Antigens, Viral, Herpesviridae

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