Feline herpesvirus type 1 glycoproteins eliciting virus neutralizing and hemagglutination-inhibiting antibodies

descriptionPublicationkeyboard_double_arrow_right Article 01 Mar 1990 English Publisher:Springer Science and Business Media LLCJournal:Archives of Virology, volume 111, pages 127-132 (issn: 0304-8608, eissn: 1432-8798,

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Authors: T, Horimoto; J A, Limcumpao; Y, Tohya; E, Takahashi; T, Mikami;

doi: 10.1007/bf01310510

pmid: 2327898

Feline herpesvirus type 1 glycoproteins eliciting virus neutralizing and hemagglutination-inhibiting antibodies

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Abstract

Monoclonal antibodies (MoAbs) to feline herpesvirus type 1 (FHV-1) were produced to identify the virus-specified immunogenic proteins. When antigens recognized by the MoAbs were investigated by immunoblot and immunoprecipitation assays using FHV-1-infected cell lysate, four groups of immunogenic proteins were identified. MoAbs directed against 60 kDa, 113 kDa, and 143 kDa/108 kDa glycoproteins had virus neutralizing activities, but those against 170 kDa protein did not. Furthermore, MoAbs to the 60 kDa glycoprotein also showed hemagglutination-inhibition activity, indicating that this glycoprotein might be the hemagglutinin.

Related Organizations

University of Tokyo
Japan

Keywords

Mice, Inbred BALB C, Antibodies, Monoclonal, Hemagglutination Inhibition Tests, Antibodies, Viral, Precipitin Tests, Molecular Weight, Mice, Viral Proteins, Neutralization Tests, Animals, Electrophoresis, Polyacrylamide Gel, Antigens, Viral, Herpesviridae, Glycoproteins

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