Effect of mazindol on brain dopamine turnover in spiperone-treated rats
Copyright policy )Effect of mazindol on brain dopamine turnover in spiperone-treated rats
Mazindol, an anorexic drug, caused a large increase in brain 3, 4-dihydroxyphenylacetic acid (DOPAC) concentration in spiperone-pretreated rats. The increase was dose-related over a 1--10 mg/kg dose range of mazindol and was maximum within 1 hour after maxzindol injection into rats pretreated 1 hour previously with spiperone. In spiperone-pretreated rats, mazindol accelerated the disappearance of dopamine after the inhibition of dopamine synthesis by alpha-methyltyrosine. Mazindol apparently resembles amfonelic acid, methylphenidate, and cocaine in facilitating the impulse-mediated release of dopamine.
- Eli Lilly (United States) United States
Male, Indoles, Dose-Response Relationship, Drug, Dopamine, Brain, Butyrophenones, Mazindol, Rats, Spiperone, 3,4-Dihydroxyphenylacetic Acid, Animals, Drug Interactions, Naphthyridines
Male, Indoles, Dose-Response Relationship, Drug, Dopamine, Brain, Butyrophenones, Mazindol, Rats, Spiperone, 3,4-Dihydroxyphenylacetic Acid, Animals, Drug Interactions, Naphthyridines
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