Infectious DNA of tick-borne encephalitis virus

descriptionPublicationkeyboard_double_arrow_right Article 01 Sep 1974 English Publisher:Springer Science and Business Media LLCJournal:Archiv f�r die gesamte Virusforschung, volume 45, pages 215-224 (issn: 0304-8608, eissn: 1432-8798,

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Authors: V M, Zhdanov; N N, Bogomolova; V I, Gavrilov; O G, Andzhaparidze; P G, Deryabin; A N, Astakhova;

doi: 10.1007/bf01249684

pmid: 4418614

Infectious DNA of tick-borne encephalitis virus

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Abstract

A system of human cells (HEp2) chronically infected with tick-borne encephalitis virus was studied. The cells produce infectious ribonucleoprotein both intracellular and extracellular. The production of the viral ribonucleoprotein is sensitive to actinomycin D. Hybridization experiments revealed virus-specific sequences in the cellular DNA. With DNA from chronically infected cells the virus could be transfected to sensitive cells.

Keywords

Transcription, Genetic, Nucleic Acid Hybridization, DNA, Neoplasm, Tritium, Cell Line, Encephalitis Viruses, Tick-Borne, Viral Proteins, Nucleoproteins, DNA, Viral, Carcinoma, Squamous Cell, Dactinomycin, Humans, RNA, Viral, Laryngeal Neoplasms, Uridine

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