descriptionPublicationkeyboard_double_arrow_right Article 01 Dec 1972 English Publisher:Springer Science and Business Media LLCJournal:Archiv f�r die gesamte Virusforschung, volume 39, pages 376-380 (issn: 0304-8608, eissn: 1432-8798,

Authors: J M, Eustatia; E, Maase; P, van Helden; J, van der Veen;

doi: 10.1007/bf01241017

pmid: 4345950

Viral replication in mouse macrophages

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Abstract

Cultures of mouse peritoneal macrophages were capable of supporting the growth of vesicular stomatitis virus (VSV), mengovirus, mouse hepatitis virus (MHV-3 and MHV-S), and reovirus type 3. Age of the cultures and peritoneal stimulation of macrophages appeared to influence this capacity. Increased viral replication was found in cultures one or more days old and in cultures of stimulated macrophages. Phytohemagglutinin (PHA)-stimulated mouse lymphocytes were relatively resistant; only VSV and mengovirus were capable of replicating in these cells.

Related Organizations

Radboud University Nijmegen
Netherlands

Keywords

Murine hepatitis virus, Time Factors, Macrophages, Mengovirus, Reoviridae, Virus Replication, Stimulation, Chemical, Vesicular stomatitis Indiana virus, Parainfluenza Virus 1, Human, Mice, Inbred C57BL, Mice, Cytopathogenic Effect, Viral, Lectins, Thioglycolates, Animals, Simplexvirus, Lymphocytes, Peritoneum, Cells, Cultured

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