Properties of transfected strains of tick-borne encephalitis virus

descriptionPublicationkeyboard_double_arrow_right Article 01 Sep 1974 English Publisher:Springer Science and Business Media LLCJournal:Archiv f�r die gesamte Virusforschung, volume 46, pages 248-252 (issn: 0304-8608, eissn: 1432-8798,

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Authors: V I, Gavrilov; N N, Bogomolova; P G, Deryabin; A V, Astakhova; O G, Andzhaparidze; V M, Zhidanov;

doi: 10.1007/bf01240067

pmid: 4615651

Properties of transfected strains of tick-borne encephalitis virus

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Abstract

Four strains of tick-borne encephalitis virus transfected by DNA from chronically infected cells were studied. The viruses induced cytopathic effect in a line of swine embryo kidney cells and inapparent infection in suckling mice. Treatment of the cells with DEAE-dextran increased infectious titres and cytopathic action of the viruses. One substrain revealed an extreme degree of attenuation and showed cytopathic activity only in the presence of DEAE-dextran.

Keywords

Virulence, Swine, Brain, Fluorescent Antibody Technique, Genetic Variation, Dextrans, Hemagglutination Tests, Kidney, Virus Replication, Cell Line, Encephalitis Viruses, Tick-Borne, Mice, Cytopathogenic Effect, Viral, Neutralization Tests, DNA, Viral, Carcinoma, Squamous Cell, Centrifugation, Density Gradient, Animals, Humans, Laryngeal Neoplasms

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