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Publication . Article . 2005

Chromosomal localization of the gene for a human cytosolic thyroid hormone binding protein homologous to the subunit of pyruvate kinase, subtype M2

Nicholas C. Popescu; Sheue-yann Cheng;
Open Access  
Published: 26 Feb 2005 Journal: Somatic Cell and Molecular Genetics, volume 16, pages 593-598 (issn: 0740-7750, eissn: 1572-9931, Copyright policy )
Publisher: Springer Science and Business Media LLC
Abstract
A cDNA for the gene that encodes a human cytosolic thyroid hormone binding protein (p58) recently has been isolated and sequenced. Analysis of the p58 sequence indicates that it is identical to the subunit of pyruvate kinase, subtype M2. By in situ hybridization, the gene for p58 was mapped to 15q24–25. This localization shows that the p58 gene is not linked to the L-type of pyruvate kinase, which is located on chromosome 1. The p58 gene was found to be activated in several forms of cancer. Current localization will permit us to assess the effect of alterations involving chromosome 15 on the structure and activity of the p58 gene in neoplasms or chromosome syndromes.
Subjects by Vocabulary

Microsoft Academic Graph classification: Pyruvate kinase RFC5 SCN3A Biology Protein subunit Molecular biology PKM2 Biochemistry MAP3K7 Cyclin-dependent kinase 4 biology.protein Gene cluster

Subjects

Cell Biology, Genetics, General Medicine

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