Metabolism of deoxycytidine in isolated perfused organs

descriptionPublicationkeyboard_double_arrow_right Article 01 Dec 1972 English Publisher:Springer Science and Business Media LLCJournal:Biophysik, volume 8, pages 333-341 (issn: 0301-634X, eissn: 1432-2099,

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Authors: G B, Gerber; B, Zicha; J, Deroo; J P, De Cock; E, Geyer;

doi: 10.1007/bf01190619

pmid: 4638814

Metabolism of deoxycytidine in isolated perfused organs

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Abstract

The metabolism of deoxycytidine-U-14C was studied in isolated perfused normal and regenerating rat liver, in perfused rat intestine and in isolated perfused mouse liver. A technique to perfuse mouse liver is described. Catabolism of dCyd is very slow in organs of the rat whereas it is rapid in those of the mouse. Nevertheless, incorporation into liver DNA does not differ markedly between the species. The quantitative aspects of dCyd metabolism in the isolated organs are discussed.

Related Organizations

European Atomic Energy Community
United Kingdom

Keywords

Male, Carbon Isotopes, Mice, Inbred BALB C, Deoxyribonucleosides, Cytidine, DNA, Liver Regeneration, Rats, Perfusion, Mice, Liver, Animals, Intestinal Mucosa

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