Effect of cyproheptadine on neuronal ultrastructure in the arcuate nucleus of the rat hypothalamus

descriptionPublicationkeyboard_double_arrow_right Article 01 Sep 1985 English Publisher:Springer Science and Business Media LLCJournal:Neuroscience and Behavioral Physiology, volume 15, pages 415-419 (issn: 0097-0549, eissn: 1573-899X,

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Authors: I I, Drozdovich; V M, Gordienko;

doi: 10.1007/bf01184028

pmid: 4094668

Effect of cyproheptadine on neuronal ultrastructure in the arcuate nucleus of the rat hypothalamus

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Abstract

1. Cyproheptadine depresses neuron function in the hypothalamic arcuate nucleus, to a degree that depends on the total dose administered. 2. Under the influence of cyproheptadine release of synthesized neurohormones from AN neurons is inhibited and this may be one mechanism of its therapeutic effect in Cushing's disease.

Related Organizations

Institute of Endocrinology
Czech Republic

Keywords

Male, Arcuate Nucleus of Hypothalamus, Cyproheptadine, Rats, Inbred Strains, Cytoplasmic Granules, Endoplasmic Reticulum, Mitochondria, Rats, Microscopy, Electron, Animals

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