Structure of 21-fluoro-4,9(11)-pregnadiene-3,20-dion-17α-yl acetate, C23H29O4F

descriptionPublicationkeyboard_double_arrow_right Article 01 Oct 1990 English Publisher:Springer Science and Business Media LLCJournal:Journal of Crystallographic and Spectroscopic Research, volume 20, pages 441-445 (issn: 0277-8068, eissn: 1572-8854,

Copyright policy )

Authors: Zdzisław Gałdecki; Paweł Grochulski; Zdzisław Wawrzak; William L. Duax; Phyllis D. Strong;

doi: 10.1007/bf01180111

Structure of 21-fluoro-4,9(11)-pregnadiene-3,20-dion-17α-yl acetate, C23H29O4F

- Summary
- Metrics

Abstract

The crystal and molecular structure of 21-fluoro-4,9(ll)-pregnadiene-3,20-dion-17a-yl acetate has been determined by X-ray diffraction methods;P212121,a=15.827(4),b=16.912(4),c=7.513(2) A,Z=4;R=0.062, (R w =0.065) for 2028 unique observed reflections. The progesterone side chain has an unusual conformation; the C16-C17-C20-O20 torsion angle is 173.1(4)°. Molecular mechanics calculations suggest that this conformation may be cuased by 17α-acetoxy substituent and the additional double bond between C9 and C11.

Related Organizations

Impact byBIP!

	selected citations These citations are derived from selected sources. This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	0
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Average
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Average
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Average