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Bioscience Reports
Article . 1985 . Peer-reviewed
Data sources: Crossref
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Bioscience Reports
Article . 1986
Data sources: Europe PubMed Central
https://dx.doi.org/10.1007/bf0...
Article
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C1r serine proteinase of human complement: A case of intramolecular autolytic activation

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 1985 English Publisher:Portland Press Ltd.Journal:Bioscience Reports, volume 5, pages 831-837 (issn: 0144-8463, eissn: 1573-4935, Copyright policy )
Authors: G J, Arlaud; M G, Colomb; C L, Villiers;

doi: 10.1007/bf01119894

pmid: 3006820

C1r serine proteinase of human complement: A case of intramolecular autolytic activation

Abstract

This paper presents a short review of our contribution to the knowledge of the structure and function of human Clr, the activation unit of C1, the first component of the classical pathway of complement. On the basis of the domain structure of Clr, a model accounting for its autolytic activation mechanism is proposed. We suggest that this represents the basic mechanism of C1 function.

Related Organizations
Keywords

Enzyme Activation, Kinetics, Complement Activating Enzymes, Complement C1r, Macromolecular Substances, Endopeptidases, Serine Endopeptidases, Homeostasis, Humans, Complement Activation

  • BIP!
    Impact byBIP!
    selected citations
    These citations are derived from selected sources.
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 11
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Average
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 Top 10%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    		 Top 10%
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
11
Average
Top 10%
Top 10%
gold