Cholesterol as a target for toxins

descriptionPublicationkeyboard_double_arrow_right Article 01 Apr 1990 English Publisher:Portland Press Ltd.Journal:Bioscience Reports, volume 10, pages 127-130 (issn: 0144-8463, eissn: 1573-4935,

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Authors: B, de Kruijff;

doi: 10.1007/bf01116571

pmid: 1694094

Cholesterol as a target for toxins

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Abstract

A mechanism is proposed for the way in which cholesterol facilitates channel formation by polyene antibiotics and bacterial protein toxins. Central elements of the model are: (i) interactions between the ring system of the sterol and rigid elements of the polyene or toxin molecule, and (ii) the specific orientation of cholesterol within the membrane.

Related Organizations

Utrecht University
Netherlands
University Museum Utrecht
Netherlands

Keywords

Chemistry, Cholesterol, Chemical Phenomena, Amphotericin B, Bacterial Toxins, Molecular Sequence Data, Amino Acid Sequence, Models, Biological, Ion Channels

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