Stability of polyadenylated mRNA in pig lymphocytes

descriptionPublicationkeyboard_double_arrow_right Article 01 Jul 1981 English Publisher:Portland Press Ltd.Journal:Bioscience Reports, volume 1, pages 539-545 (issn: 0144-8463, eissn: 1573-4935,

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Authors: D M, Wallace; J E, Kay;

doi: 10.1007/bf01116302

pmid: 6170357

Stability of polyadenylated mRNA in pig lymphocytes

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Abstract

The stability of cytoplasmic poly(A)-containing mRNA in unstimulated pig lymphocytes has been determined by [3H]poly(U) hybridization after actinomycin D treatment. This approach has shown that the majority of the mRNA is much more unstable than has been suggested by earlier pulse-chase experiments, and has a half-life of between 1 and 2 h.

Related Organizations

National Institute of Health
Pakistan
National Institutes of Health
United States
National Cancer Institute
United States
University of Sussex
United Kingdom

Keywords

Swine, Dactinomycin, Animals, RNA, Blood Proteins, Lymphocytes, RNA, Messenger, Poly A, Half-Life

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