descriptionPublicationkeyboard_double_arrow_right Article 01 Feb 1982 English Publisher:Portland Press Ltd.Journal:Bioscience Reports, volume 2, pages 115-116 (issn: 0144-8463, eissn: 1573-4935,

Authors: Eva Gagerman; Ezz-Eldin S. M. El-Denshary; Inge-Bert Täljedal; Nabila A. Ismail; Janove Sehlin;

doi: 10.1007/bf01116177

pmid: 7039712

Bromocriptine and insulin secretion

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Abstract

The dopaminergic drug bromocriptine inhibited the release of insulin from isolated mouse pancreatic islets. The effect was counteracted by haloperidol or pimozide. It is suggested that insulin release may be inhibited through activation of D-2 dopaminergic receptors in the pancreatic beta-cells.

Related Organizations

Umeå University
Sweden

Keywords

Pimozide, In Vitro Techniques, Receptors, Dopamine, Islets of Langerhans, Mice, Insulin Secretion, Animals, Haloperidol, Insulin, Bromocriptine

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