Dialectics in carrier research: The ADP/ATP carrier and the uncoupling protein
Copyright policy )Dialectics in carrier research: The ADP/ATP carrier and the uncoupling protein
A concise review is given of the research in our laboratory on the ADP/ATP carrier (AAC) and the uncoupling protein (UCP). Although homologous proteins, their widely different functions and contrasts are stressed. The pioneer role of research on the AAC, not only for the mitochondrial but also for other carriers, and the present state of their structure-function relationship is reviewed. The function of UCP as a highly regulated H+ carrier is described in contrast to the largely unregulated ADP/ATP exchange in AAC. General principles of carrier catalysis as derived from studies on the AAC and UCP are elucidated.
Mammals, Binding Sites, Molecular Sequence Data, Membrane Proteins, Biological Transport, Intracellular Membranes, Ion Channels, Mitochondria, Protein Structure, Tertiary, Adenosine Diphosphate, Mitochondrial Proteins, Adenosine Triphosphate, Adipose Tissue, Brown, Animals, Amino Acid Sequence, Protons, Carrier Proteins, Energy Metabolism, Mitochondrial ADP, ATP Translocases, Phylogeny
Mammals, Binding Sites, Molecular Sequence Data, Membrane Proteins, Biological Transport, Intracellular Membranes, Ion Channels, Mitochondria, Protein Structure, Tertiary, Adenosine Diphosphate, Mitochondrial Proteins, Adenosine Triphosphate, Adipose Tissue, Brown, Animals, Amino Acid Sequence, Protons, Carrier Proteins, Energy Metabolism, Mitochondrial ADP, ATP Translocases, Phylogeny
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