Depsipeptides. Communication 25. Structure and total synthesis of enniatins A and B

descriptionPublicationkeyboard_double_arrow_right Article 01 Sep 1965 English Publisher:Springer Science and Business Media LLCJournal:Bulletin of the Academy of Sciences, USSR Division of Chemical Science, volume 14, pages 1,584-1,589 (issn: 0568-5230, eissn: 1573-9171,

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Authors: M. M. Shemyakin; Yu. A. Ovchinnikov; A. A. Kiryushkin; V. T. Ivanov;

doi: 10.1007/bf01083803

Depsipeptides. Communication 25. Structure and total synthesis of enniatins A and B

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Abstract

1. Enniatins A and B have the cyclohexadepsipeptide structures (XX) and (VIII) respectively, and these were confirmed by the total synthesis of these antibiotics. 2. Two analogs of enniatins A and B were synthesized: the cyclohexadepsipeptide (XXI) and the cyclooctadepsipeptide (XII). 3. Among the depsipeptide cyclic polymer -homologs investigated the highest antimicrobic activity is possessed by cyclohexadepsipeptides, and the activity of the latter depends relatively little on the structures of the methylamino acid residues of which they are composed.

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Russian Academy of Sciences
Russian Federation

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