Epsilon-Aminocaproic acid therapy in ulcerative colitis

descriptionPublicationkeyboard_double_arrow_right Article 01 Nov 1973 English Publisher:Springer Science and Business Media LLCJournal:The American Journal of Digestive Diseases, volume 18, pages 959-965 (issn: 0002-9211, eissn: 1573-2568,

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Authors: N A, Mowat; A S, Douglas; P W, Brunt; J A, McIntosh; P C, King; K, Boddy;

doi: 10.1007/bf01072440

pmid: 4201370

Epsilon-Aminocaproic acid therapy in ulcerative colitis

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Abstract

A double-blind cross-over trial of the effect of Epsilon-Aminocaproic acid (EACA) versus placebo on gastrointestinal blood loss in 13 patients with proctocolitis showed no statistically significant reduction in blood loss recorded by the disappearance rate, as detected by whole-body monitoring of parenterally administered59Fe. Moreover, there was poor correlation between sigmoidoscopic findings, using a standard grading, and estimated colonic blood loss. Patients with severe proctocolitis were excluded from the trial. This is the first reported controlled trial of the effect of EACA on blood loss in proctocolitis.

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University Research Co (United States)
United States

Keywords

Adult, Aminocaproates, Male, Clinical Trials as Topic, Iron Radioisotopes, Blood Volume, Adolescent, Body Weight, Administration, Oral, Middle Aged, Whole-Body Counting, Body Height, Placebos, Humans, Colitis, Ulcerative, Female, Gastrointestinal Hemorrhage, Sigmoidoscopy, Aged

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