Mean residence time in peripheral tissue

descriptionPublicationkeyboard_double_arrow_right Article 01 Aug 1987 English Publisher:Springer Science and Business Media LLCJournal:Journal of Pharmacokinetics and Biopharmaceutics, volume 15, pages 439-450 (issn: 0090-466X,

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Authors: P J, McNamara; J C, Fleishaker; T L, Hayden;

doi: 10.1007/bf01066523

pmid: 3681668

Mean residence time in peripheral tissue

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Abstract

The published methods for determining the mean residence time for drugs in peripheral tissue are reviewed in terms of assumptions involved, advantages and disadvantages. A method for determining mean transit time in peripheral tissue is proposed; this may be a more useful indicator of the tissue retention properties for drug compounds.

Related Organizations

University of Kentucky
United States

Keywords

Humans, Pharmacokinetics, Tissue Distribution, Models, Biological, Half-Life

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