Bias and variance of extrapolated tails for area-under-the-curve (AUC) and area-under-the-moment-curve (AUMC)

descriptionPublicationkeyboard_double_arrow_right Article 01 Oct 1992 English Publisher:Springer Science and Business Media LLCJournal:Journal of Pharmacokinetics and Biopharmaceutics, volume 20, pages 501-510 (issn: 0090-466X,

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Authors: R D, Purves;

doi: 10.1007/bf01061468

pmid: 1287199

Bias and variance of extrapolated tails for area-under-the-curve (AUC) and area-under-the-moment-curve (AUMC)

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Abstract

The usual formulas for the extrapolated values of AUC and AUMC from tn to infinity produce estimates that are biased. An empirical correction factor is shown to reduce both bias and variance of estimates. The fitted value Cz at the last time-point tn should normally be used in the formulas, rather than the measured concentration Cn. Nonlinear least squares methods offer no advantage over the fitting of a straight line to ln (C).

Related Organizations

University of Otago
New Zealand

Keywords

Analysis of Variance, Bias, Methods, Pharmacokinetics, Least-Squares Analysis, Mathematical Computing, Models, Biological

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