Time course of carbamazepine self-induction

descriptionPublicationkeyboard_double_arrow_right Article 01 Feb 1979 English Publisher:Springer Science and Business Media LLCJournal:Journal of Pharmacokinetics and Biopharmaceutics, volume 7, pages 63-68 (issn: 0090-466X,

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Authors: P J, McNamara; W A, Colburn; M, Gibaldi;

doi: 10.1007/bf01059441

pmid: 458557

Time course of carbamazepine self-induction

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Abstract

Carbamazepine concentrations in plasma during repetitive oral dosing were analyzed by means of a nonlinear, variable parameter, regression program (VARPARM) assuming dose-to-dose changes in the apparent elimination rate constant of the drug. There was evidence of significant self-induction of carbamazepine metabolism as early as 1 or 2 days after initiation of the multiple-dose study. Additional self-induction appears to occur after about 2 weeks of treatment. The time course of carbamazepine self-induction appears to be complex, discontinuous, and prolonged.

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Keywords

Male, Kinetics, Carbamazepine, Time Factors, Computers, Humans, Models, Biological

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