We undertake the comparison between Ludwig von Bertalanffy's General Systems Theory and Alexandr Bodganov's Tektology as two theories proposing a holistic interpretation of reality and claiming to solve problems which are unsolvable via conventional philosophic and scientific theories and methodologies. Basic misunderstandings by some Soviet authors regarding the nature of these theories — especially in the case of Tektology — are pointed out. The comparison is made in what concerns the general origins and purposes of the theories, their approaches to the problem of organization, their treatment of mathematics and their understanding of the cybernetic concept of regulation.