Enhancement of producing catharanthine by suspension growth ofCatharanthus roseus

descriptionPublicationkeyboard_double_arrow_right Article 01 Aug 1990 English Publisher:Springer Science and Business Media LLCJournal:Biotechnology Letters, volume 12, pages 603-608 (issn: 0141-5492, eissn: 1573-6776,

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Authors: Hyung H. Park; Suk K. Choi; Jae K. Kang; Hyeon Y. Lee;

doi: 10.1007/bf01030760

Enhancement of producing catharanthine by suspension growth ofCatharanthus roseus

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Abstract

Increased production of catharanthine (about 200 μg/mL) was obtained at low light intensity under chemostat cultivation as compared with batch and fed-batch processes. Photo-inhibition was observed at high light intensity. Cells after being frozen with 5% DMSO produced more catharanthine (up to 350 μg/L) in batch culture than those from conventional culture techniques.

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