IgG production kinetics in serum free media

descriptionPublicationkeyboard_double_arrow_right Article 01 Aug 1986 English Publisher:Springer Science and Business Media LLCJournal:Biotechnology Letters, volume 8, pages 529-534 (issn: 0141-5492, eissn: 1573-6776,

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Authors: John P. Tharakan; Pao C. Chau;

doi: 10.1007/bf01028077

IgG production kinetics in serum free media

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Abstract

A murine hybridoma (455) was cultured in four different serum free media formulations, and a newborn calf serum supplemented medium was used as a basis of comparison. The serum supplemented medium supports a higher cell growth rate and results in a higher IgG titer. However, the antibody secretion rate on a per cell basis is higher in the serum free media, indicating that serum could be inhibitory to antibody secretion. The results identify the possibility of a least eliminating serum during the monoclonal antibody production phase.

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University of California, San Diego
United States

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