A histochemical method for dihydrofolate reductase

descriptionPublicationkeyboard_double_arrow_right Article 01 Jul 1970 English Publisher:Springer Science and Business Media LLCJournal:The Histochemical Journal, volume 2, pages 289-295 (issn: 0018-2214, eissn: 1573-6865,

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Authors: D, Onicescu; L, Taşcă; E, Trutza;

doi: 10.1007/bf01004997

pmid: 4112997

A histochemical method for dihydrofolate reductase

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Abstract

A histochemical method for the detection of dihydrofolate reductase (5,6,7,8-tetrahydrofolate: NADP oxidoreductase, E.C. 1.5.1.3) is described. With this method, the highest enzyme activity has been found in hepatocytes, nephrocytes, intestinal epithelium and connective tissue cells. In myocardial and skeletal muscle fibres and in leukocytes, the activity was of medium intensity, whereas neurons exhibited no activity.

Keywords

Neurons, Histocytochemistry, Muscles, Myocardium, Brain, Epithelial Cells, Kidney, Epithelium, Rats, Folic Acid, Liver, Connective Tissue, Spectrophotometry, Cerebellum, Adrenal Glands, Leukocytes, Animals, Intestinal Mucosa, NADP, Connective Tissue Cells

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