Physiopathology of cellular peptides

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 01 Jan 1971 English Publisher:Springer Science and Business Media LLCJournal:Naunyn-Schmiedebergs Archiv f�r Pharmakologie, volume 269, pages 163-172 (issn: 0028-1298, eissn: 1432-1912,

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Authors: R, Keller;

doi: 10.1007/bf01003034

pmid: 4254275

Physiopathology of cellular peptides

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Abstract

Cationic polypeptides isolated from cytoplasmatic granules of polymorphonuclear leukocytes and platelets are biologically active. Low molecular weight, arginine-rich polypeptides show a specific mast celldegranulating and histamine-releasing effect and increase vascular permeability by this mechanism. Higher molecular cationic polypeptides from subcellular granules increase vascular permeability by a histamineindependent mechanism, promote emigration of leukocytes and show antibacterial activity.

Keywords

Cell Nucleus, Inflammation, Ions, Guinea Pigs, Cytoplasmic Granules, Rats, Molecular Weight, Leukocytes, Animals, Humans, Peptides

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