Nerve growth factor antibodies recognize neurotrophin-3
Copyright policy )Nerve growth factor antibodies recognize neurotrophin-3
The immunological properties of the neurotrophins NGF, BDNF, and NT-3 were compared using polyclonal and monoclonal antibodies against the beta subunit of mouse NGF. Affinity-purified anti-NGF IgG consistently recognized NGF and NT-3 on Western blots, and inhibited the trophic activity of NGF and NT-3 but not BDNF. In contrast, anti-NGF monoclonal antibodies did not block the trophic activity of either NT-3 or BDNF. These results are consistent with the greater structural overlap between NGF and NT-3 than between NGF and BDNF.
Base Sequence, Blotting, Western, Molecular Sequence Data, Antibodies, Monoclonal, Nerve Tissue Proteins, Antibodies, Mice, Neurotrophin 3, Animals, Nerve Growth Factors
Base Sequence, Blotting, Western, Molecular Sequence Data, Antibodies, Monoclonal, Nerve Tissue Proteins, Antibodies, Mice, Neurotrophin 3, Animals, Nerve Growth Factors
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