d-amphetamine binding to brain lipid
Copyright policy )d-amphetamine binding to brain lipid
The interaction of d-amphetamine with several brain tissue components has been investigated. A brain lipid extract and a number of individual phospholipids were found to bind d-amphetamine when measured by means of a hexane-buffer partition coefficient technique. Phosphatidylserine showed the greatest binding and phosphatidylethanolamine and dipalmitoyllecithin were also effective. Phospholipid binding of d-amphetamine was shown to be related to fatty acid composition. Cholesterol and ganglioside did not bind. It is suggested that phospholipid binding of d-amphetamine may play a role in the pharmacological action of this drug.
- University of California, Los Angeles United States
- Hospital de Especialidades Carlos Andrade Marín Ecuador
Membrane Lipids, Structure-Activity Relationship, Dextroamphetamine, Models, Chemical, Solubility, Animals, Brain, Cattle, Hydrogen-Ion Concentration, Phospholipids
Membrane Lipids, Structure-Activity Relationship, Dextroamphetamine, Models, Chemical, Solubility, Animals, Brain, Cattle, Hydrogen-Ion Concentration, Phospholipids
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