The transport of cytidine into rat brain in vivo, and its conversion into cytidine metabolites

descriptionPublicationkeyboard_double_arrow_right Article 01 Oct 1982 Italy English Publisher:Springer Science and Business Media LLCJournal:Neurochemical Research, volume 7, pages 1,199-1,207 (issn: 0364-3190, eissn: 1573-6903,

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Authors: G. Trovarelli; PALMERINI, Carlo Alberto; A. Floridi; G. L. Piccinin; G. Porcellati;

doi: 10.1007/bf00965891

pmid: 7155275

handle: 11391/921494

The transport of cytidine into rat brain in vivo, and its conversion into cytidine metabolites

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Abstract

Double-labeled cytidine, with a 3H/14C isotope ratio of 20.00, has been intraventricularly injected into the brain of young rats, and its fate followed up to 90 min from administration together time-course of labeling. The injected nucleoside enters the brain as an intact molecule and is immediately utilized without prior degradation. Cytidine is actively converted into uridine and CMP, the latter being then transformed by a stepwise mechanism into CDP and CTP, and finally into CDP-choline and CDP-ethanolamine. The results indicate that administered cytidine represents a compound likely to enter metabolic events, which lead to CDP-choline and CDP-ethanolamine synthesis, and presumably to phospholipid production.

Country

Italy

Related Organizations

University of Perugia
Italy

Keywords

Male, cytidine; rat brain; metabolites, Cytidine Diphosphate Choline, Brain, Biological Transport, Rats, Inbred Strains, Cytidine, Rats, Cytidine Monophosphate, Animals, Female

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