Fluoroacetate and fluorocitrate: Mechanism of action

descriptionPublicationkeyboard_double_arrow_right Article 01 Sep 1991 English Publisher:Springer Science and Business Media LLCJournal:Neurochemical Research, volume 16, pages 1,055-1,058 (issn: 0364-3190, eissn: 1573-6903,

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Authors: D D, Clarke;

doi: 10.1007/bf00965850

pmid: 1784332

Fluoroacetate and fluorocitrate: Mechanism of action

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Abstract

The concept of lethal synthesis as suggested by Peters is reviewed in the light of the more recent work in this area. It is suggested that fluorocitrate is a "suicide" substrate for aconitase rather than a competitive inhibitor as originally suggested. The use of these substances to study glial-neuronal relationships is considered.

Related Organizations

Fordham University
United States

Keywords

Aconitate Hydratase, Neurons, Fluoroacetates, Animals, Citrates, Neuroglia

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