Vertebrate GABA receptors

descriptionPublicationkeyboard_double_arrow_right Article 01 Jun 1978 English Publisher:Springer Science and Business Media LLCJournal:Neurochemical Research, volume 3, pages 263-280 (issn: 0364-3190, eissn: 1573-6903,

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Authors: F V, DeFeudis;

doi: 10.1007/bf00965574

pmid: 370671

Vertebrate GABA receptors

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Abstract

Physiologic-pharmacologic studies in vivo and with tissue cultures have revealed that synaptic GABA receptors exist in the vertebrate CNS. The GABA antagonist, bicuculline, can be used to detect synaptic GABA receptors in both the presence and absence of Na+, even though GABA binding to cerebral subcellular fractions occurs mainly to transport (uptake) receptors in the presence of Na+.

Keywords

Receptors, Drug, Sodium, Brain, Bicuculline, Mice, Cricetinae, Vertebrates, Animals, Cells, Cultured, gamma-Aminobutyric Acid

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