Biological effects of bovine glia maturation factor on glial cells in culture

descriptionPublicationkeyboard_double_arrow_right Article 01 Apr 1981 English Publisher:Springer Science and Business Media LLCJournal:Neurochemical Research, volume 6, pages 401-412 (issn: 0364-3190, eissn: 1573-6903,

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Authors: T, Kato; Y, Yamakawa; R, Lim; D E, Turriff; R, Tanaka;

doi: 10.1007/bf00963855

pmid: 7266748

Biological effects of bovine glia maturation factor on glial cells in culture

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Abstract

Optimal bioassay conditions for bovine glia maturation factor (GMF) were determined among glial cells from normal glioblasts to glioma cells. Rat glioblasts 4-8 days after subculture show the highest response t GMF with regard to morphological transformation and mitogenic activity. Bovine GMF enhances DNA synthesis of rat glioblasts at 12 h after stimulation; maximum incorporation of [methyl-3H]thymidine was detected at 18 h. GMF increases twofold the saturation density of rat glioblasts but does not alter that of C6 astrocytoma cells. The apparent inhibition of mitogenic activity of high doses of GMF is seen in both normal and malignant glial cells.

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Keywords

Glia Maturation Factor, Cell Survival, Brain, Mitosis, Cell Differentiation, Nerve Tissue Proteins, DNA, Astrocytoma, Rats, Animals, Cattle, Neuroglia, Cells, Cultured

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