Biomolecules from HCN

descriptionPublicationkeyboard_double_arrow_right Article , Part of book or chapter of book 01 Jan 1974 English Publisher:Springer Science and Business Media LLCJournal:Origins of Life, volume 5, pages 153-157 (issn: 0302-1688, eissn: 1573-0875,

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Authors: J P, Ferris; J D, Wos; T J, Ryan; A P, Lobo; D B, Donner;

doi: 10.1007/bf00927020 , 10.1007/978-94-010-2239-2_12 , 10.1007/978-94-015-1118-6_11

pmid: 4366907

Biomolecules from HCN

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Abstract

The mechanism of the condensation of dilute aqueous solutions of HCN and the products formed by these reactions have been investigated. The initial HCN condensation reactions yield3, a compound which is readily oxidized to4. A similar oxidation of5 to6 was also observed. Urea is formed on hydrolysis of4. The oxidation-reduction products formed from HCN may be in part a consequence of the oxidation of3. It has been established by combination GC/MS that the amino acids glycine, diaminosuccinic acid, α-amino-isobutyric acid, aspartic acid, alanine and isoleucine are released on acid hydrolysis of the ‘HCN polymer’. Hydantoin (7), 5,5-dimethylhydantoin (8) and 5-carboxymethyldenehydantoin (10) are also released on acid hydrolysis of the HCN condensation products. The direct conversion of the dicarbonyl derivative, of diaminosuccinic acid to orotic acid via10 at pH 8 has been observed. This conversion suggests a direct route to pyrimidines from HCN.

Related Organizations

Rensselaer Polytechnic Institute
United States

Keywords

Geological Phenomena, Oxalates, Chromatography, Gas, Chemical Phenomena, Macromolecular Substances, Hydrolysis, Origin of Life, Geology, Hydrogen-Ion Concentration, Chromatography, Ion Exchange, Biological Evolution, Mass Spectrometry, Molecular Weight, Chemistry, Pyrimidines, Models, Chemical, Purines, Hydrogen Cyanide, Amino Acids, Oxidation-Reduction

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