Hydroxyl radical-scavenging property of indomethacin

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 1994 English Publisher:Springer Science and Business Media LLCJournal:Molecular and Cellular Biochemistry, volume 136, pages 139-144 (issn: 0300-8177, eissn: 1573-4919,

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Authors: K, Prasad; V A, Laxdal;

doi: 10.1007/bf00926074

pmid: 7845367

Hydroxyl radical-scavenging property of indomethacin

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Abstract

The ability of indomethacin to scavenge hydroxyl radical (.OH) using high pressure liquid chromatography (HPLC) was investigated. .OH radical was generated by photolysis of H2O2 (1.5-10 mmoles/L) with UV light and was trapped with salicyclic acid (500 nmoles). H2O2 produced .OH in a concentration-dependent manner as estimated by .OH adduct products 2,3- and 2,5-dihydroxybenzoic acid (DHBA). Indomethacin in increasing concentrations (5-600 mumoles/L) produced increasing inhibition of generation of 2,3-DHBA (7-67%) and of 2,5-DHBA (7-77%). The results indicate that indomethacin scavenges .OH in a concentration-dependent manner.

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Keywords

Photolysis, Hydroxyl Radical, Ultraviolet Rays, Gentisates, Indomethacin, Hydroxybenzoates, Free Radical Scavengers, Sensitivity and Specificity, Chromatography, High Pressure Liquid

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