Permeability factor contaminating hyaluronidase preparations

descriptionPublicationkeyboard_double_arrow_right Article 01 Sep 1979 English Publisher:Springer Science and Business Media LLCJournal:Inflammation, volume 3, pages 447-451 (issn: 0360-3997, eissn: 1573-2576,

Copyright policy )

Authors: J C, Houck; C M, Chang;

doi: 10.1007/bf00913502

pmid: 511298

Permeability factor contaminating hyaluronidase preparations

- Summary
- Subjects
- Metrics

Abstract

Both crude and highly purified testicular hyaluronidase preparations have been shown to contain a component which increases the permeability of the microcirculation in rat skin. This permeability activity had an isoelectric point of 7.4 while hyaluronidase was 9.4. It also could be separated from hyaluronidase by acrylamide gel electrophoresis. The permeability factor was not inhibited by serum and may explain previous observations that hyaluronidase preparations decrease the ischemia and necrosis appropriate to experimental myocardial infarction in vivo.

Keywords

Male, Hyaluronoglucosaminidase, Capillaries, Rats, Capillary Permeability, Testis, Animals, Electrophoresis, Polyacrylamide Gel, Isoelectric Focusing, Drug Contamination, Skin

Impact byBIP!

	selected citations These citations are derived from selected sources. This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	14
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Average
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%