Arachidonic acid aggregates neutrophils

descriptionPublicationkeyboard_double_arrow_right Article 01 Sep 1979 English Publisher:Springer Science and Business Media LLCJournal:Inflammation, volume 3, pages 431-436 (issn: 0360-3997, eissn: 1573-2576,

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Authors: J T, O'Flaherty; H S, Showell; E L, Becker; P A, Ward;

doi: 10.1007/bf00913500

pmid: 511297

Arachidonic acid aggregates neutrophils

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Abstract

Arachidonic acid, but not several structurally similar fatty acids, stimulated neutrophils in suspension to aggregate; this effect was blocked by 5, 8, 11, 14-eicosatetraynoic acid, an inhibitor of arachidonic acid metabolism. Analagous to platelets, arachidonate may be a precursor of active metabolites which mediate neutrophil responses.

Related Organizations

University of Connecticut Health Center
United States

Keywords

L-Lactate Dehydrogenase, Neutrophils, Humans, Muramidase, Arachidonic Acids, Stimulation, Chemical, Cell Aggregation

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