Neighbors are an informal resource who may act individually to provide socioemotional support to each other as well as collectively to ameliorate problems in their residential environment. To explore when neighbors are likely to interact and provide aid and emotional support for each other, 702 residents living in a neighborhood in Nashville, Tennessee, were interviewed during 1978. Factor analysis was used to cluster several variables of individual characteristics of residents related to neighboring. Other indices assessed the block environment. Neighboring activities were found to be associated with an individual's psychological investment in his neighborhood as well as his rootedness and integration on his block, a positive sense of well-being, sex, and life stage. At the neighborhood block level, homogeneity of socioeconomic status (SES) contributed to neighbor relations along with indices of an individual's similarity to block residents. Implications are discussed for the development of neighboring activities and neighborhood organizations.