Jeffreys-Bullen P and PKP travel-time residuals observed at more than 50 seismic stations distributed along Italy and surrounding areas in the time interval 1962–1979, indicate the complex velocity pattern of this region. Strong lateral velocity inhomogeneities and low velocity zones are required to explain the observed pattern of residuals. In particular, late arrivals of about 1 sec are observed in the Apenninic mountain range, requiring both greater crustal thickness and low velocity layers, coherent with seismic refraction data and surface wave dispersion measurements. The seismic stations located in the Western and Eastern Alps indicate the presence of high velocities. In the Western Alps the strong azimuthal variation of residuals and the high values of early arrivals have a close relationship to the Ivrea body, an intrusive crustal complex characterized by a velocity as high as 7–7.2 km/sec. A travel-time inversion performed with theAki et al. (1977) block model, confirms the peculiar characteristics and the sharp variations in the lithosphere of the whole Italian region, with values of velocity perturbations between many adjacent blocks, ranging in size from 50 to 100 km, and independent from the earth parametrization chosen, reaching values up to 10% in the lithospheric part and 5% in the asthenosphere. 3-D inversion requires also high velocity along the Tyrrhenian coastal margin, equivalent to an uprise of major crustal and lithospheric discontinuities along this part of the Italian peninsula. Moreover low velocity material must be present in the northern part of the Adriatic foreland, in the lithosphere-asthenosphere system, closely related to the stress and seismicity pattern, and the lateral bending of the lithosphere in the same region.