Mechanism of the protective action of cysteamine in frozen aqueous solutions of DNA and cysteamine

descriptionPublicationkeyboard_double_arrow_right Article 01 Jun 1972 English Publisher:Springer Science and Business Media LLCJournal:Bulletin of the Academy of Sciences of the USSR Division of Chemical Science, volume 21, pages 1,383-1,385 (issn: 0568-5230, eissn: 1573-9171,

Authors: M. N. Sultankhodzhaeva; V. A. Sharpatyi;

doi: 10.1007/bf00854574

Mechanism of the protective action of cysteamine in frozen aqueous solutions of DNA and cysteamine

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Abstract

1. Cysteamine (CA) radicals of the RS type are recorded instead of radicals with the thymine (TH) structure, observed in DNA solutions, when an aqueous frozen solution of DNA and CA, irradiated at 77°K, is warmed up. 2. The formation of RS is explained by transfer of H from CA to the DNA macroradical and by a process which includes interaction of DNA anion radicals with CA with subsequent conversion of the CA anion radical.

Related Organizations

Russian Academy of Sciences
Russian Federation

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