P-fimbriae vaccines

descriptionPublicationkeyboard_double_arrow_right Article 01 Dec 1989 English Publisher:Springer Science and Business Media LLCJournal:Pediatric Nephrology, volume 3, pages 386-390 (issn: 0931-041X, eissn: 1432-198X,

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Authors: M B, Kaack; A, Pere; T K, Korhonen; S B, Svenson; J A, Roberts;

doi: 10.1007/bf00850212

pmid: 2577146

P-fimbriae vaccines

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Abstract

To test for cross-protective capacity of two different P-fimbriae vaccines we vaccinated baboons with fimbriae purified from either Escherichia coli strain ER2 or strain JR1. The vaccinated animals showed elevated antibody titers to P-fimbriae from each of the E. coli strains used, suggesting cross-reactivity as was expected from the results of immunoprecipitation of the fimbriae. Enzyme-linked immunosorbent assay inhibition by heterologous P-fimbriae proved this to be true immunologic cross-reactivity.

Related Organizations

University of Helsinki
Finland

Keywords

Pyelonephritis, Virulence, Cross Reactions, Antibodies, Bacterial, Fimbriae, Bacterial, Bacterial Vaccines, Escherichia coli, Animals, Escherichia coli Infections, Papio

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