Specific binding of (+)-3H-SKF 10047 by mouse splenocytes

descriptionPublicationkeyboard_double_arrow_right Article 01 Dec 1987 English Publisher:Springer Science and Business Media LLCJournal:Bulletin of Experimental Biology and Medicine, volume 104, pages 1,703-1,707 (issn: 0007-4888, eissn: 1573-8221,

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Authors: K N, Iarygin; G T, Sukhikh; V A, Vinogradov; G N, Kryzhanovskiĭ;

doi: 10.1007/bf00836005

pmid: 3689964

Specific binding of (+)-3H-SKF 10047 by mouse splenocytes

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Abstract

Stereoselective, saturable, reversible and temperature-dependent binding of ligand of sigma opioid receptors (+)-3H-SKF 10047 to mouse splenocytes has been demonstrated. The estimated Kd value of this interaction (20-100 nM) was similar to that of (+)-3H-SKF 10047-sigma receptor complex. The binding capacity was 100 molecules per cell. A comparatively low affinity, non-stereoselective and temperature-independent binding of (+)-3H-SKF 10047 to mouse splenocytes has also been found.

Related Organizations

Academy of Medical Sciences
United Kingdom

Keywords

Male, Mice, Inbred Strains, In Vitro Techniques, Tritium, Mice, Phenazocine, Isomerism, Species Specificity, Animals, Spleen

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