Etoposide phosphate, the water soluble prodrug of etoposide

descriptionPublicationkeyboard_double_arrow_right Article 01 Oct 1996 Netherlands English Publisher:Springer Science and Business Media LLCJournal:Pharmacy World and Science, volume 18, pages 163-170 (issn: 0928-1231, eissn: 1573-739X,

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Authors: Witterland, A.H.I.; Koks, C.H.W.; Beijnen, J.H.;

doi: 10.1007/bf00820727

pmid: 8933576

Etoposide phosphate, the water soluble prodrug of etoposide

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Abstract

Etoposide (Vepesid) is a widely used drug in a variety of neoplasms. To improve the pharmaceutical characteristics of etoposide, etoposide phosphate (Etopophos, Bristol-Myers Squibb) has been developed as a prodrug. Etoposide phosphate is the phosphate ester derivative of etoposide. In comparison to the parent compound, etoposide phosphate is highly soluble in water and can be readily formulated for intravenous use, resulting in higher clinical application. This paper presents information on the pharmaceutical properties and the current status of etoposide phosphate in clinical trials.

Country

Netherlands

Related Organizations

Utrecht University
Netherlands
Antoni van Leeuwenhoek Hospital
Netherlands
Netherlands Heart Institute
Netherlands

Keywords

Drugmisbruik en verslaving, Clinical Trials, Phase I as Topic, Farmacie(FARM), Water, Biomedische technologie en medicijnen, Antineoplastic Agents, Phytogenic, Organophosphorus Compounds, SDG 3 - Good Health and Well-being, Solubility, Medical technology, Humans, Prodrugs, Public Health, Analytical chemistry, Etoposide

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