Dicyclohexylcarbodiimide as inducer of mitochondrial Ca2+ release
Copyright policy )Dicyclohexylcarbodiimide as inducer of mitochondrial Ca2+ release
The effect of the alkylating reagent dicyclohexylcarbodiimide (DCCD) on mitochondrial Ca2+ content was studied. The results obtained indicate that DCCD at a concentration of 100 microM induces mitochondrial Ca2+ efflux. This reaction is accompanied by an increasing energy drain on the system, stimulation of oxygen consumption, and mitochondrial swelling. These DCCD effects can be partially suppressed by supplementing the incubation medium with 1 mM phosphate. By electrophoretic analysis on polyacrylamide-sodium dodecyl sulfate, it was found that DCCD binds to a membrane component with an Mr of 20 to 29 kDa.
In Vitro Techniques, Kidney, Mitochondria, Phosphates, Rats, Oxygen Consumption, Dicyclohexylcarbodiimide, Animals, Calcium, Energy Metabolism, Mitochondrial Swelling
In Vitro Techniques, Kidney, Mitochondria, Phosphates, Rats, Oxygen Consumption, Dicyclohexylcarbodiimide, Animals, Calcium, Energy Metabolism, Mitochondrial Swelling
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