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Effect of the phosphonic analogue of tyrosine on tyrosine iodination

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 1994Publisher:Springer Science and Business Media LLCJournal:Amino Acids, volume 7, pages 97-103 (issn: 0939-4451, eissn: 1438-2199,

Authors: Eugène Neuzil; A. Iron; A. Cassaigne;

doi: 10.1007/bf00808451

pmid: 24185978

Effect of the phosphonic analogue of tyrosine on tyrosine iodination

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Abstract

Depositing ofDL-1-amino-2-(p-hydroxyphenyl)-ethylphosphonic acid (Tyr-P) on the chicken embryo induced a dose dependent decrease of the iodine uptake by the embryonic thyroid. Tyr-P interfered on iodination of tyrosine when tested with hog thyroid peroxidase (TPO) and with bovine lactoperoxidase (LPO); the analogue was recognized by the two enzymes but its affinity for TPO and LPO was respectively 3 and 7 fold higher compared with that of the natural substrate, suggesting that Tyr-P may act as an iodine trap.

Related Organizations

University of Bordeaux
France
University of Bordeaux
France

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