
doi: 10.1007/bf00772112
It is possible to evaluate the extent of the course of the reaction under consideration and to calculate the values of the degrees of the electrostatic binding (Qel) of ketamin AB by the investigated copolymers from the amount of the isolated acid. The compositions of the synthesized carboxyl-containing co~olymers of VP, the values of the intrinsic viscosities of their aqueous-salt solutions ([n]~1N KCI), as well as the values of Qel are presented in Table i. The analysis of the data in Table I indicates that the degree of the electrostatic binding of katamin AB with the copolymers (I)-(III) increases with the increase in the relative molar content of katamin AB in the solution (~) in the range from 0 to I. The comparison of the values of Qel for the copolymers (I)-I and (1)-3, (II)-I and (II)-3, and (III)-i and (III)-3 correspondingly indicates that the portion of the molecules of the antiseptic connected by an ionic bond to the polymer-carrier increases with the increase in the amount of the ionogenic carboxyl groups in the copolymer at a constant value of ~. Among the copolymers of close composition (I)-2, (II)-1, (III)-i and (I)-3, (11)-2, and (111)-2 at the same value of ~, the values of Qel found for the copolymers of VP-~A are significantly less than those of the polymers VP-+[AA and VP-AA. The observed phenomenon is caused by differences in the microstructure of the copolymers of VP utilized. It is known [9] that the copo!ymer s of VP-~A and VP-AA are characterized by a high degree of the microInstitute of High-Molecular Compounds, Academy of Sciences of the USSR, Leningrad. R.
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