Radioprotector and antineoplastic activity of certain tetrazole derivatives

descriptionPublicationkeyboard_double_arrow_right Article 01 May 1986 English Publisher:Springer Science and Business Media LLCJournal:Pharmaceutical Chemistry Journal, volume 20, pages 336-340 (issn: 0091-150X, eissn: 1573-9031,

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Authors: V. G. Kitaeva; R. I. Ishmetova; N. I. Latosh; R. M. Malkina; G. M. Anoghina;

doi: 10.1007/bf00758615

Radioprotector and antineoplastic activity of certain tetrazole derivatives

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Abstract

For a modification of the biological activity of the 5-substituted tetrazoles that were studied earlier, the authors synthesized products of their alkylation by Mannich bases from phenols, since substances with good radioprotective properties have been detected among the phenols. The acute toxicity was determined on mice and treatment of the data on toxicity of the compounds studied was performed according to the method of Litchfield and Wilcoson, and LD/sub 16/, LD/sub 50/, and LD/sub 84/ were determined.

Related Organizations

Russian Academy of Sciences
Russian Federation

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