Antibodies in the study of multiple drug resistance
Copyright policy )Antibodies in the study of multiple drug resistance
Multidrug resistance (MDR) is a major problem in cancer chemotherapy. As P-glycoprotein is the key molecule in MDR, many investigators have constructed anti-P-glycoprotein monoclonal antibodies (MAbs). Those antibodies, including MRK16 and C219, were used for elucidation of the mechanism of MDR and for overcoming of MDR. This article describes the characterization of the antibodies against the P-glycoprotein and other proteins of multidrug-resistant tumor cells, and discusses the therapeutic implication of the antibodies.
- University of Tokyo Japan
- National Cancer Research Institute United Kingdom
Mice, Inbred BALB C, Cell Survival, Drug Resistance, Antibodies, Monoclonal, Antineoplastic Agents, Neoplasms, Experimental, Cell Line, Mice, Tumor Cells, Cultured, Animals, Humans, Immunotherapy, Glycoproteins
Mice, Inbred BALB C, Cell Survival, Drug Resistance, Antibodies, Monoclonal, Antineoplastic Agents, Neoplasms, Experimental, Cell Line, Mice, Tumor Cells, Cultured, Animals, Humans, Immunotherapy, Glycoproteins
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