Mapping of gene loci in the Q13?Q15 region of chromosome 12

descriptionPublicationkeyboard_double_arrow_right Article 01 Jun 1995 English Publisher:Springer Science and Business Media LLCJournal:Chromosome Research, volume 3, pages 261-262 (issn: 0967-3849, eissn: 1573-6849,

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Authors: E L, Mitchell; G R, White; M F, Santibanez-Koref; J M, Varley; J, Heighway;

doi: 10.1007/bf00713052

pmid: 7606365

Mapping of gene loci in the Q13?Q15 region of chromosome 12

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Abstract

The gene loci CDK4, GLI, CHOP and MDM2 have been mapped to the q13-q15 region of chromosome 12. Using fluorescence in situ hybridization onto simultaneously DAPI-banded metaphase chromosomes and interphase nuclei, we have more precisely mapped and ordered these loci, together with a number of Genethon microsatellite markers. GLI and CHOP localize to 12q13.3-14.1, CDK4 to 12q14 and MDM2 to 12q14.3-q15, and the gene order is cen-GLI/CHOP-CDK4-MDM2. The Genethon microsatellites D12S80 and D12S83 flank MDM2.

Related Organizations

Cancer Research UK Manchester Institute
United Kingdom
Christie Hospital NHS Foundation Trust
United Kingdom

Keywords

Genetic Markers, Oncogene Proteins, Chromosomes, Human, Pair 12, Chromosome Mapping, Cyclin-Dependent Kinase 4, Nuclear Proteins, Proto-Oncogene Proteins c-mdm2, Protein Serine-Threonine Kinases, Zinc Finger Protein GLI1, Cyclin-Dependent Kinases, DNA-Binding Proteins, Proto-Oncogene Proteins, CCAAT-Enhancer-Binding Proteins, Trans-Activators, Humans, In Situ Hybridization, Fluorescence, Transcription Factor CHOP, Transcription Factors

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