An experimental model for selective production of neoplasms of the peripheral nervous system
Copyright policy )An experimental model for selective production of neoplasms of the peripheral nervous system
Ninety-three tumors of the peripheral nervous system (PNS) were produced in 30 male Fischer (CDF) rats following intravenous injection of 10 mg/kg of N-methyl N-nitrosourea (MNU) twice weekly for 9 weeks. The high susceptibility of CDF rats to an optimal dose of MNU provides a useful experimental model to study induction and pathogenesis of tumors of the PNS. In this model PNS tumors occur in a high percentage of animals, multiple PNS tumors are common, the sites of development are predictable, and the well-differentiated morphology is similar to the morphology of naturally occurring neurinomas of man and animals.
- The Ohio State University United States
Male, Time Factors, Brain Neoplasms, Neoplasms, Experimental, Nitrosourea Compounds, Rats, Lymphatic System, Meninges, Peripheral Nervous System Neoplasms, Animals, Neurilemmoma
Male, Time Factors, Brain Neoplasms, Neoplasms, Experimental, Nitrosourea Compounds, Rats, Lymphatic System, Meninges, Peripheral Nervous System Neoplasms, Animals, Neurilemmoma
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).20 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!