Lafora's disease and brain calcifications

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 1988 English Publisher:Springer Science and Business Media LLCJournal:Acta Neuropathologica, volume 76, pages 532-538 (issn: 0001-6322, eissn: 1432-0533,

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Authors: S, Oster; E, Reske-Nielsen; I, Bruun;

doi: 10.1007/bf00686395

pmid: 3142202

Lafora's disease and brain calcifications

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Abstract

The brain from a 22-year-old man with progressive myoclonal epilepsy (Lafora's disease) was examined. Besides widespread inclusion bodies in the nerve cells calcifications were seen on the inner and outer surface of the brain. No gliosis was present but the astrocytes were enlarged. They were unrelated to the inclusion bodies, as demonstrated in combined stainings with glial fibrillary acidic protein (GFAP)-PAS or GFAP-Bodian. A transport of an abnormal metabolic product is suggested.

Keywords

Adult, Male, Brain Diseases, Calcinosis, Humans, Epilepsies, Myoclonic

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